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Genetic material is injected directly into the fertilized egg which is then implanted back into a mouse and allowed to come to term

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doi: 10.3923/pjbs.2011.742.746 33

1 Introduction Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disorder that includes loss of tolerance to self-antigen and subsequent activation of autoreactive T and B cells, production of dysregulated cytokines ( The available treatment methods in SLE are chiefly immunosuppressants