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Springer, Berlin, pp 167184 Urruticoechea A, Alemany R, Balart J, Villanueva A, Vinals F, Capella G (2010) Recent advances in cancer therapy: an overview

High-risk patients including those on long-term or high-dose metformin, older adults, and those with additional risk factors should be considered for periodic B12 monitoring

This review examines recent research on CTCs/ disseminated tumor cells (DTCs), summarizing their key characteristics during metastasis in vivo, including epithelial-mesenchymal transition (EMT), tumor dormancy, organotropism and awakening