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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]

2000, 71 (1 Suppl): 343S-8S

Quicker graying occurs due to reduced melanin production, influenced by genetics

These indicators could be useful CSF biomarkers but will need additional studies to assess and confirm how such changes correlate with severity of the lesion, and time after injury