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To identify potentially eligible cases, the applicant searched the FY 2021 MedPAR file using only the listed ankle fusion procedure codes, but we note that that the proposed indication for this device is for use in failed ankle fusions and failed arthroplasties

The ROS produced upon engagement of these receptors can then alter downstream signaling by oxidizing specific cysteine residues within a variety of intracellular proteins including protein kinases, protein phosphatases, adaptor proteins, calcium channels, and transcription factors

Pharmacological suppression and genetic ablation of these channels ameliorate the inflammatory and degenerative retinal phenotypes associated with ocular hypertension (119), suggesting possible roles in glaucoma

Ludwig DS, Apovian CM, Aronne LJ, Astrup A, Cantley LC, Ebbeling CB, et al