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In patients undergoing prophylaxis following elective hip surgery or hip fracture surgery, the total clearance of fondaparinux is approximately 25% lower in patients with mild renal impairment (CrCl 50 mL/min to 80 mL/min), approximately 40% lower in patients with moderate renal impairment (CrCl 30 mL/min to 50 mL/min), and approximately 55% lower in patients with severe renal impairment (less than 30 mL/min) compared to patients with normal renal function