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Int J Mol Sci 24:2019 Ejike UC, Chan CJ, Okechukwu PN, Lim RLH (2020) New advances and potentials of fungal Immunomodulatory proteins for therapeutic purposes

Intriguingly, immune-responsive gene 1 (IRG1) redirects citrate to itaconate, which synergizes with NO to block succinate dehydrogenase (SDH), forming the second breakpoint, which accumulates inflammatory succinate [14]