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DNA methylation and MiRNA bidirectional feedback loop Positive regulation: DNA methylation silences tumor suppressor MiRNAs In drug-resistant cells, hypermethylation of tumor-suppressing miRNA promoters leads to their silencing, forming a positive feedback loop of DNA methylation/miRNA silencing/activation of drug resistance genes. For example, miR-130b is downregulated in cisplatin-resistant cells due to hypermethylation of its promoter

For example graphene quantum dot-coated VO 2 array electrode exhibited a high lithium capacity retention of 94% after 1,500 cycles (Zhang et al., 2015)