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We found significantly higher GDH activity in our non-SCLC-A cell lines and, accordingly, GDH expressions in non-SCLC-A human tumor samples obtained from rapid autopsies

In addition, zinc plays a vital role in the thyroid hormones metabolism by regulating thyrotropin-releasing hormone (TRH) and TSH synthesis and modulating the structures of essential transcription factors involved in synthesizing thyroid hormones (177, 178)

This prior addition of extracellular CAT completely inhibited the death of the two spheroids, indicating their sensitivity to pharmacological Vit-C-mediated H 2 O 2 generation and thus confirming the contribution of H 2 O 2 in the observed cytotoxicity mediated by Vit-C