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Limitations of the study Despite the cellular (neural precursor cells, oligodendroglia, and microglia) and molecular mechanisms (folate cycle and anti-oxidative stress metabolism) underlying the beneficial effects of leucovorin and dyclonine in oligodendrogenesis and myelin repair shown here, follow up studies are crucial to unravel the particular mechanisms underlying the effects of each compound in each pathological context, and in cell types, including neurons and astrocytes