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This effectively blocks the normal sulfur oxidation pathway and disrupts sulfur homeostasis ( Caenorhabditis elegans , SQOR family members have diverged such that SQRD-1 serves as the primary H 2 S detoxification enzyme (able to use either ubiquinone or rhodoquinone as electron acceptor), whereas SQRD-2 acts as a negative regulator that accelerates recovery from H 2 S exposure ( SQOR and ferroptosis Ferroptosis is an iron-dependent form of programmed cell death driven by the accumulation of iron-catalyzed lipid peroxides in cell membranes, which causes lethal membrane damage (Tang and Kroemer, 2020)

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The difficulty in identifying hGS as a member of the family is due in part to a rare gene permutation which has resulted in a circular shift of the conserved secondary structure elements in hGS with respect to the other known ATP-grasp proteins

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