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As Figure 4D demonstrates, parasites were incubated with or without 10 M halofantrine in various conditions as follows: (a) media, (b) HEPES-buffered saline (HBS) for 'No inhibition', (c) HBS with sodium azide for 'Inhibition of F1-ATPase and cytochrome c oxidase', (d) HBS without glucose, but supplemented with 2-deoxy-D-glucose and sodium pyruvate for 'Inhibition of glycolysis', and (e) HBS without glucose, but supplemented with sodium azide, 2-deoxy-D-glucose and sodium pyruvate for 'Inhibition of both'

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100,120,121,122 An N-terminal intrinsically disordered peptide sequence has been shown to bind another haem moiety, although its function remains to be determined

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