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Besides, several putative inherited disorders related to folate metabolism are described in the literature, for instance: DHFR deficiency, cellular uptake defects, and 5,10-methyleneTHF cyclohydrolase deficiency (part of the trifunctional enzyme 5,10-methyleneTHF dehydrogenase 1 MTHFD1 )

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These solutes, such as proteins, proline, and sugars, act as osmotic regulators, enhancing the ability of roots to absorb water, maintaining cell turgor, improving stomatal conductance, preventing membrane damage, and scavenging free radicals 2

Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance