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CAFs, MCs, ECs, adipocytes, and immune subsets all contribute to a protective and immunosuppressive niche that shields tumor cells from platinum-induced damage

PanYYoonSSunJHuangZLeeCAllenMet al

The process initiates with radical-induced proton abstraction from deoxyribose, leading to multiple reaction intermediates and ribose fragments through hydrogen atom transfer (HAT) ( 2 forms a sugar peroxyl radical that converts into a hydroperoxide intermediate