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The presence of high serum bicarbonate could indicate chronic respiratory acidosis [typical of chronic obstructive pulmonary disease (COPD)] or metabolic alkalosis (secondary to vomiting, use of thiazide diuretics, or excess mineralocorticoids) (336)

Studies using radiolabeled GHK analogs found that 6075% of the administered dose is recovered in urine within 12 hours, with the remainder metabolized to individual amino acids that re-enter general circulation and cellular protein synthesis pathways

(For a deeper dive, see our guide to peptides for gut health.) Potential contributors include: Food sensitivities Dysbiosis Poor diet Chronic stress Infections Antibiotic overuse Alcohol excess Environmental factors such as exposure to toxins or irritants Functional medicine frequently focuses on restoring gut health because improving the gut often improves inflammation elsewhere in the body

But in reality, your skin needs some level of healthy sebum to stay balanced