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One of the consequences of excessive Ca2+ uptake by mitochondria is that mitochondrial respiration and mitochondrial membrane potential increase, leading to an increased likelihood of electron leakage and reactive oxygen species (ROS) production (197)

With the disease progression, the degree of reductions in N -acetylaspartate tends to accentuate in patients with chronic schizophrenia (versus first episode patients

In TNF--stimulated chondrocytes, TBK1 overexpression reversed fragmentation, restored membrane potential, reduced mtROS, and inhibited apoptosis (88)

doi: 10.2337/diabetes.54.2.311 63 NettoLESMachadoL