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Cardiovascular Safety Heart rate increases of approximately 2-6 beats per minute have been observed with orforglipron across clinical trials, consistent with the class effect of GLP-1 receptor agonists

AOD-9604 is not an approved human medicine in the EU or USA

Vitamin B12 deficiency If left untreated, vitamin B deficiency can harm your brain and nervous system, leading to issues such as: Incontinence (not being able to control your pee or poop) Nerve issues, such as numbness, weakness, or nerve pain Erectile dysfunction (not being able to get an erect penis) Paralysis (not being able to move your body) Memory loss Paranoia (feeling like others are trying to hurt you) If you dont have symptoms but are at risk of low B12 levels, your doctor might also want you to have regular tests

clinical trial registered on ClinicalTrials.gov