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J Cell Sci 112:19151923

Cytoplasmic DNA sensing by KU complex in aged CD4(+) T cell potentiates T cell activation and aging-related autoimmune inflammation

Compared with the NC group, crystal formation in the urolithiasis model group was signifi-cantly increased, and renal tubules were dilated and vacuolated, leading to glomerular degeneration

Therefore, the structure of the erastin-bound SLC7A11 will inspire further research to design better versions of erastin as ferroptosis inducers and anti-cancer drugs