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This bacterial defence mechanism has been shown to promote an anti-inflammatory response and induce a disease-tolerant immune response ( Psuedomonas aeruginosa and Staphylococcus aureus utilise itaconate as a carbon source to establish a persistent infection and support the development of biofilms ( Figure 1B )

Lamoth et al., 2016)

Erastin binds to the xCT-4F2hc complex, where its chlorophenoxy group interacts with the Phe254 residue in xCT TM6b, inhibiting xCT activity, depleting intracellular cysteine and glutathione, and inducing ferroptosis [41]

Its specificity makes it a subject of interest for different researchers and scientists