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elegans have shown that mitochondrial stress in the F0 generation can influence bioenergetic function across subsequent generations, evidence for transmissible mitochondrial effects in mammals remains limited ( Statements Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation

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Interestingly, in sunitinib-treated mice, there is a higher infiltration of CD4 + and CD8 + within the tumor with a lower CTLA-4 and PD-1 expression, preventing T cells exhaustion [86]