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Donnez J, Hudecek R, Donnez O, et al

Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications

In many patients, this is in the wrist where there is damage or deterioration that is causing pain and limiting function

Encouraging studies indicate that B-12 has the potential to decelerate cognitive deterioration in individuals grappling with dementia and the initial stages of Alzheimer's disease