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10.1038/nrendo.2013.67 57 KhorramO.LaughlinG

Acute toxicity of aflatoxins M1 and M2 in one-day-old ducklings

It is not entirely clear how increased glucose flux through the hexosamine pathway mediates hyperglycemia-mduced increases in the gene transcription of key genes such as TGF-, TNF-1 and PAI-1, however, it has been shown that the transcription factor Sp1 regulates hyperglycemia-induced activation of the PAI-1 promoter in vascular smooth muscle cells [119]