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Additionally, NRH, the reduced form of nicotinamide ribose (NR), ameliorated aminoglycoside-induced hearing loss and attenuated HC damage by increasing NAD + levels and activating SIRT1 in the cochlea [117]

HCV proteins can be divided into two categories: proteins essential for particle assembly and release (Core, E1, E2, NS2, p7) and proteins required for viral RNA replication (NS3, NS4A, NS4B, NS5A, NS5B) 4