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High-dose prescription EPA (icosapent ethyl) demonstrates robust evidence of MACE risk reduction in hypertriglyceridemic, high-risk populations, while mixed EPA + DHA supplements exhibit more variable efficacy

The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)