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Gastro-intestinal symptoms score was assessed based on the score of Adam and collaborators 16 as follows: Parents were asked to indicate whether their children had experienced specific GI symptoms nausea, vomiting, bloating, abdominal cramps, early satiety, eructation or heartburn, loss of appetite, retrosternal discomfort and epigastric pain or abdominal pain over the past month

Rucker R, Chowanadisai W, Nakano M

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Inter-individual variability was assumed exponential, and the full covariance matrix of the random effects was estimated