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Hyland and colleagues (2004) found that there was a gradient in the cessation rate by age of initiation: 37.3 percent of those who started smoking when they were age 15 or younger had quit, 41.3 percent of those who started smoking when they were ages 16 to 19 years had quit, and 47.6 percent of those who started smoking when they were older than age 19 years had quit

However, cancer cells may eliminate damaged mitochondria and escape apoptosis via mitophagy, which leads to the development of resistance

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