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Therapeutic Class: Active Ingredients: Methotrexate Methotrexate Injection is an antimetabolite and antifolate drug used to treat certain types of cancer

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Previous studies have shown altered thiol status and reduced glutathione availability in patients with organic acidemias, including MMA and PA [40,41,42,43,44], alongside evidence of elevated reactive oxygen species and impaired antioxidant capacity [45, 46]