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BHB, the predominant ketone body in circulation, not only serves as an energy substrate, but also inhibits class I histone deacetylases, suppresses NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3) inflammasome activation, and modulates nuclear factor kappa B (NF-B) activity, thereby influencing gene expression related to antioxidant defence, inflammation, and mitochondrial function [21, 37, 38]

Although the mechanisms of hepatic IRI are largely unknown, several targets have been revealed to be associated with its pathogenesis by preclinical studies such as proliferators-activated receptor , family with sequence similarity 3A, and some noncoding RNAs (Yang et al., 2018)

The majority of studies have assessed the effect of menopause on dermal structure and function

Yang et al, 1992