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Authors contributions Study concept (TS, MK), study design (TS, MK), preclinical experiments, data analysis, drafting of the manuscript (TS), supervision of data collection, review (MK, SLJ, CJ), revision (MK), conception and analysis of biochemical observations (SLJ), conception and performance of cell culture studies, data analysis, and data interpretation (CJ)

The use of contraception is also recommended in patients taking this medication

The PPAR agonist GW7647 upregulates Nr1i3 mRNA expression in sham mice but not in CLP mice, indicating that both HNF4 and PPAR may contribute to the downregulation of Nr1i3 in CLP ( Figure 2E )

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