While retaining their binding to cartilage, these fragments were able to carry payloads such as an MMP-cleavable form of viral IL-10 60 and soluble TNF receptor II, 33 enabling the in vivo imaging of murine OA cartilage
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These drugs block histamine H1 receptors and may influence immune responses, including the reduction of the Th2 response (259, 260)
Within the endoplasmic reticulum, the ER-associated degradation (ERAD) pathway and the UPR collectively detect folding stress, reduce protein load, and enhance repair capacity
