l carnitine and egg quality effects of metabolisable energy L-carnitine levels and fat sources L-carnitine is an amino acid

Deficiency leads to methylmalonic acid accumulation, which can cause neurological damage over time

Using multiple high-throughput proteomics assays in two independent cohorts of konzo-affected children compared to unrelated individuals (Discovery) or their unaffected sibling (Validation) respectively, we demonstrate that levels of the critical plasma-based antioxidant enzyme Glutathione Peroxidase 3 (GPx3) are significantly reduced in those affected

Studies in adults suggest that caffeine intake also directly affects the visceral and liver fat deposition, which are strong risk factors for cardio-metabolic disease (Figure 4)

Important limitations remain: The human studies are small