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In vivo Animals Ten-week-old SpragueDawley male rats were supplied by the Animal Breeding Center of the Weizmann Institute of Science (Rehovot, Israel)

Primary hippocampal neuron cultures are used to study Dihexa's proposed effects on dendritic spine density and synaptic protein expression, typically measuring morphological changes via fluorescence microscopy and quantifying synaptic marker expression (such as PSD-95 or synaptophysin) relative to untreated controls

Seering, J., Mayol, R., Harpstead, E., Chen, T., Cook, A., & Hammer, J

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