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This document is an initiative of the Spanish Society of Internal Medicine (SEMI) in collaboration with the Spanish Society of Cardiology (SEC) and the Spanish Society of Nephrology (S.E.N.)

Inhibiting autophagy or cathepsin-B preserves morphine efficacy ( While most studies emphasize acute and sub-acute SCI pathology, the chronic phase (months to years post-injury) is marked by persistent autophagy defects, maladaptive microglial activation, and glial scar consolidation

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