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Deficiency concerns: Alcoholism intestinal and bariatric surgeries digestive disorders lack of intrinsic factor vegetarians Vegans who do not consume any animal products When you don't have enough folate and vitamin B12, deficiency can result in anemia, fatigue, irregular heartbeat, shortness of breath, hair loss, and pale skin with mouth sores

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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewings sarcoma

This facilitates its interaction with basic region leucine zipper proteins at AREs thereby enhancing the transcription of antioxidant genes