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3.5 Ferroptosis-induced disruption of the bloodbrain barrier in Alzheimers disease The bloodbrain barrier (BBB) is a critical structural interface that maintains central nervous system (CNS) homeostasis by restricting the translocation of blood-derived substances, inflammatory mediators, iron ions, and immune cells into the brain parenchyma through its tight junction architecture

In one study, 65 people with depression received either 100 mg/kg of tyrosine, 2.5 mg/kg of a common antidepressant or a placebo each day for four weeks

Cell Metab 29(5):110418.e6 [DOI] [PMC free article] [PubMed] [Google Scholar] 79.Kahlfuss S, Kaufmann U, Concepcion AR, Noyer L, Raphael D, et al