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NADPH, derived from glucose via the PPP, is the ultimate electron donor that reduces the downstream proteins in the GSH antioxidant system

n = 13 for normal group, and n = 28 for MASH group

Association between circulating metabolites in the second trimester and GDM To assess metabolic changes after GDM diagnosis, we also conducted BA, polar semi-targeted, and lipidomic analyses on sera collected from identical 236 study subjects in the second trimester

In addition, we suggest potential therapeutic strategies for fat-induced insulin resistance that target ectopic fat accumulation in liver and promote energy consumption by skeletal muscle