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Maybe, more importantly, the effect on mitochondria function from this imbalance between oxidants and antioxidants in the brain: As shown in Figure 1, mitochondrial complex I-III activity was significantly decreased as early as seven days of repeated exposure to restraint stress

Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS