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The Lancet Psychiatry, 2(1), 38-48

These studies are strictly experimental and focused on understanding sleep mechanisms

However, the studies classified at higher-level DRL tiers use higher-fidelity models or real-world settings to test design performance

Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms