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In addition, H2O2 is involved in mediating biological processes, including PCD (Desikan et al., 1998), ABA-mediated stomatal closure (Pei et al., 2000), auxin-regulated gravitropic responses (Joo et al., 2001), mechanical wounding response (Orozco-Cardenas et al., 2001), systematically acquired resistance (SAR) (Inz and Van Montagu, 1995), plant pathogen interaction (Mittler et al., 1999), and some other processes relating to both biotic and abiotic stresses (Desikan et al., 2003)

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The use of multimodal therapy is becoming widespread due to the relatively frequent ineffectiveness of pain management during monotherapy

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