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10.1016/S2215-0366(21)00395-3 Lancet Psychiatry 64 GershonM

However, the hypoxic microenvironment of the TME can induce autophagy via HIF1, downregulating MHC-I molecule expression and thereby reducing CD8 + T cell cytotoxicity (89)

p38 MAPK has been shown to inhibit oncogenic Hras (encode Hras, or Harvey Rat sarcoma virus or transforming protein p21) malignant transformation and ROS- activation of p38 signaling may trigger cell cycle arrest, suppress cell growth and division of cancer cells (Dolado et al