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It has been proven that the protective effects of taurine appear to involved antioxidant, osmoregulatory and ion regulatory activities 32

Mitochondrial dysfunction in COPD patients leads to the accumulation of TCA intermediates (e.g., citrate, alpha-ketoglutarate), while smoke-exposed mice exhibit mitochondrial dysfunction and reduced TCA cycle rate ( 6.3 Lipid metabolic reprogramming Normal lipid metabolism mainly consists of three core pathways: fatty acid -oxidation (FAO, a catabolic process), fatty acid synthesis, and cholesterol synthesis ( 6.3.1 Macrophage phenotypic polarization in lipid metabolism of COPD Macrophages are core cells regulating inflammation and metabolism in COPD lung tissue, and their phenotypic polarization is tightly coupled with FAO function ( The proportion of M1 macrophages is significantly increased in COPD lung tissue

References 1 Amigo-BenaventM.WangS.MateosR.SarriB.BravoL

Five-year cumulative incidence of HCC was higher in PNPLA3 -rs738409-GG carriers than -CC/-CG carriers: 14.1% (7.2-23.3%) vs