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After selecting the desired stoichiometry between backbone and crosslinker polymerizable functional groups, backbone and crosslinker are dissolved in DMSO and a suitable emulgator with an appropriately selected HLB value, preferably Arlacel P135, is employed to form an inverse emulsion using a mechanical stirrer and controlling the stirring speed

doi: 10.1002/pro.3519 205 MasjediAHashemiVHojjat-FarsangiMGhalamfarsaGAziziGYousefiMet al

Mitochondria-targeted nanomedicines self-assembled from GSH-responsive paclitaxel-SS-berberine conjugates can upregulate ROS levels in cancer cells, arrest cells in the G2/M phase, induce cancer cell apoptosis, and inhibit tumor growth [237]