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An alteration in the phosphorylation pattern, such as an increase in tyrosine phosphorylation, which results from pathological conditions, such as inflammation or elevated ROS, can alter the proteinprotein interactions of occludin with ZO-1, ZO-2, and ZO-3, and thereby alter the membrane integrity 75

Nanoparticles are tiny carriers usually made from lipids, polymers, or proteins designed to encapsulate peptides and protect them from enzymatic degradation while improving absorption and tissue targeting

Clinical trials involving children with ASD have shown that bumetanide not only alleviates the severity of ASD symptoms but also reduces GABA concentrations in the insular cortex

doi: 10.1101/2021.02.15.431262 82 FeyereisenR