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Additionally, the overall rhythmicity/goodness-of-fit of the extended cosine model was estimated using pseudo-F statistics or rsquared values, with a higher value indicating a more robust overall rest-activity rhythmicity [47,50]

The difference-edited GSH spectrum was generated by subtraction of the OFF and ON spectra

Clinical studies indicate that postmenopausal women exhibit a ~30% reduction in ATP production efficiency, which associates directly with decreased activity of mitochondrial complex IV, COX (118)