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L162 and C166 in the SOCS2-box region interacts with the ELOB/C protein complex to promote K48-linked polyubiquitination and degradation of SLC7A11, thus inducing ferroptosis and enhancing the radiosensitivity of liver cancer cells [223]

High VEGF expression during angiogenesis in breast cancer decreases CD8 T-cell levels via the HMG-bOX ( TOX ) pathway, thereby increasing tumor-cell tolerance to immunotherapy 70 ( Figure 3F )

[2] [4] In experimental models it has been reported to modulate several growth factors and to protect the gastrointestinal mucosa