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To date the reactivation of eight human herpesviruses (HHVs) have been identified, including Herpes Simplex Virus types 1 (HSV1) and 2 (HSV2), VaricellaZoster Virus (VZV or HHV3), Epstein-Barr Virus (EBV or HHV4), Cytomegalovirus (HCMV or HHV5), HHV6, HHV7, and Kaposis Sarcomaassociated Herpesvirus (KSHV or HHV8)

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The nuclear-encoded enzyme Mn-SOD moves into the matrix of the mitochondria, and it is a homotetramer with manganese as a cofactor and an active site

After 24 h, the culture medium was exchanged for complete culture medium containing Erastin (5 M), RSL3 (10 M), Erastin (5 M) + Ferrostatin-1 (2 M) or RSL3 (10 M) + Ferrostatin (2 M) complete culture-medium