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Management of side effects: Though side effects of semaglutide are typically mild, including nausea and diarrhea, B12 is being studied as a potential strategy to lessen these effects when compounded with semaglutide

An inadequate selenium supply impairs the synthesis of the mitochondrial envelope of sperm, which affects sperm motility and may lead to infertility (Wang et al., 2021)

FOXO4-DRI represents a peptide-based senolytic approach that is more targeted than small-molecule senolytics like dasatinib plus quercetin, which affect broader cellular pathways

Notably, however, we obtained data indicating that the prevalence of those with low IGF-1 levels was similar (27.8%) in the subjects without diabetes, suggesting that the prevalence of those with low IGF-1 levels in the present study reflects obese subjects overall