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ML162, which is selectively lethal to mutant RAS oncogene-expressing cells (with IC50s of 25 and 578 nM for HRAS G12V -expressing and wild-type RAS-expressing BJeHLT cells, respectively), is another GPX4 inhibitor to suppress tumor cell proliferation [197]

Both peptides influence extracellular matrix organization, a critical component of cartilage and synovial tissue maintenance

Advanced imaging techniques, such as atomic force microscopy (AFM) and magnetic resonance elastography (MRE), enable researchers to visualize and quantify the nanoscale mechanical properties of muscle and ligament tissues