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Further preferred is an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a sequence of at least about 500 contiguous nucleotides in the nucleotide sequence of SEQ ID NO:1

Melatonin significantly reduces iron-deficiency anaemia in vitro and in vivo and increases the osteogenic capacity of MC3T3-E1 cells by activating the Nrf2/HO-1 pathway [81]

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Excessive burden of ROS, failure of clearance mechanisms and even lack of antioxidants may lead to the accumulation of ROS and to oxidative stress [40], which are associated with genetic damage and breast cancer onset [61,62,63,64,65]