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Current research has validated the regulatory effects of certain clinical medications on the Th17/Treg balance, as summarized in Table 1

To overcome these constraints, we propose that future prospective studies implement three key strategies: (1)Systematic collection of dietary and supplemental B12 data using standardized instruments such as food frequency questionnaires

RCTs are generally stronger for testing causality, whereas cohort studies are better suited to studying long-term risk factors, natural disease progression, and situations where RCTs would be unethical or impractical