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It may then shift to include a generalized response that is triggered by a larger set of chemicals.[ref] Many researchers consider MCS to be a loss of tolerance to environmental contaminants, such as organophosphates, solvents, and heavy metals, even at concentrations considered non-toxic for most people

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3.5 Regulation of sympathetic activity Cyclic enhancement of sympathetic nerve activity is observed in OSAHS, as indicated by increased muscle sympathetic nerve activity (MSNA) (99), elevated urinary norepinephrine concentrations (100), and reduced heart rate variability (101), which persists during wakefulness (102)